Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy. Electronic address: alessandro.mengozzi@medmcs.unipi.it. Department of Surgical, Medical, Molecular and Critical Area Pathology, University of Pisa, Italy. Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy. Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK. Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark. Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Alexandra Hospital, Athens, Greece. Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria. Institute of Neuroscience, National Research Council, Padua, Italy.